PeiPei Ping - Professor of Physiology and Medicine | The Cardiac Proteomics & Signaling Laboratory at UCLA

Professor of Physiology and Medicine

Peipei Ping, PhD FAHA

Peipei Ping is Professor of Physiology and Medicine at the University of California at Los Angeles (UCLA), School of Medicine. Born in Beijing, China, she graduated from Zhejiang University in 1985 with double majors in Medicine and Bioengineering. Dr. Ping received her graduate training in cardiovascular physiology and pathology under the mentorship of Dr. Paul C Johnson at the University of Arizona. Her postdoctoral training was with Dr. James Faber at the University of North Carolina (UNC) Chapel Hill, and later with Dr. Kirk Hammond in the Molecular Cardiology Training Program (Directed by Dr. James Covell) at the University of California at San Diego (UCSD). She was promoted to Assistant Adjunct Professor at UCSD in 1995. Subsequently, she was appointed as Assistant Professor of Physiology and Medicine at the University of Louisville in 1996, and advanced to Associate Professor in 2000. In 2002, Dr. Ping was recruited by UCLA School of Medicine as Professor of Physiology and Medicine, and Director of the Proteomic Laboratory at the Cardiovascular Research Laboratories.

Dr. Peipei Ping has served on the Editorial Boards of American Journal of Physiology, Circulation Research, Journal of Molecular and Cellular Cardiology, Circulation, Proteomics, and Journal of Proteome Research. She is Fellow of the American Physiological Society (APS), Cardiovascular Section (2001-current), and Fellow of American Heart Association (FAHA) (1998-current). She has served on the APS Award Committee; on the AHA Basic Science Council Program Committee; She also serves on the council of International Society of Heart Research (ISHR, 2006 – 2012); on the Environmental Protective Agency (EPA) Board of Scientific Review (2005−2007); and on the Sarnoff Cardiology Scientific Advisory Committee.

Dr. Peipei Ping has also a devoted service record at NIH; she served on the NIH CSR CVA study section, and on the study section of Myocardial Ischemia and Metabolism (MIM) as a member and Chairperson (2003−2006). In 2002, she was appointed to the first NHLBI Director’s Clinical Proteomic Working Group; subsequently, she served as the chair of the NHLBI evaluation committee on Clinical Proteomic Centers (2005), and was instrumental in establishing the NHLBI Clinical Proteomic Centers. She continuous to play a leadership role in the External Advisory Panel for these NHLBI Clinical Proteomic Programs (2004-current). She has recently been appointed as Chairperson of NHLBI working group on the role of mitochondria in cardiovascular diseases (2007−2008).

Dr. Peipei Ping is actively involved with the Human Proteome Organization (HUPO). She was recruited by Sam Hanash as one of the 17 founding council members; she has served on the HUPO Council (2001-current) and Executive Committee. She was elected as Co-Leader of the Cell Model Proteome Initiative (2002); as co chairs of the Cardiovascular Proteomic Initiative (2006−2007); as Chair of Education Committee (2003−2004) of HPPP; as an EC member of Human Plasma Proteome Initiative (2002-current as Chair of HUPO Award Committee (2003−2007); as Co-Chair of Scientific Program Committee (2004, 2006, 2009); and as Chair of HUPO Publications Committee (2005−2008). She has successfully led a committee effort in establishing official journals for HUPO. Dr. Ping served as the Secretary General of US-HUPO (2003−2005) under the Presidency of Catherine Fenselau; and is currently the Secretary General of International-HUPO (2007−2008) under the Presidency of Rolf Apweiler.

publications by Peipei Ping

1
Bell AW, et al. A HUPO test sample study reveals common problems in mass spectrometry-based proteomics. Nat Methods. 2009.
2
Chen XF, Zhou LX, Liu YD, Ping P , Chen YH, Cao M, Sun J. [Comparative analysis of three different surgical approaches to varicocelectomy]. Zhonghua Nan Ke Xue. 2009;15:413 – 6.
3
Gomes AV, Young GW, Wang Y, Zong C, Eghbali M, Drews O, Lu H, Stefani E, Ping P . Contrasting proteome biology and functional heterogeneity of the 20 S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 2009;8:302 – 15.
4
Lu G, Sun H, She P, Youn JY, Warburton S, Ping P , Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009;119:1678 – 87.
5
Mayr M, Liem D, Zhang J, Li X, Avliyakulov NK, Yang JI, Young G, Vondriska TM, Ladroue C, Madhu B, Griffiths JR, Gomes A, Xu Q, Ping P . Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J Mol Cell Cardiol. 2009;46:268 – 77.
6
Ping P . Getting to the heart of proteomics. N Engl J Med. 2009;360:532 – 4.
7
Rodriguez H, Snyder M, Uhlen M, Andrews P, Beavis R, Borchers C, Chalkley RJ, Cho SY, Cottingham K, Dunn M, Dylag T, Edgar R, Hare P, Heck AJ, Hirsch RF, Kennedy K, Kolar P, Kraus HJ, Mallick P, Nesvizhskii A, Ping P , Ponten F, Yang L, Yates JR, Stein SE, Hermjakob H, Kinsinger CR, Apweiler R. Recommendations from the 2008 International Summit on Proteomics Data Release and Sharing Policy: the Amsterdam principles. J Proteome Res. 2009;8:3689 – 92.
8
Ujwal R, Cascio D, Chaptal V, Ping P , Abramson J. Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation. Channels (Austin). 2009;3:167 – 70.
9
Wu HY, Tseng VS, Chen LC, Chang YC, Ping P , Liao CC, Tsay YG, Yu JS, Liao PC. Combining alkaline phosphatase treatment and hybrid linear ion trap/Orbitrap high mass accuracy liquid chromatography-mass spectrometry data for the efficient and confident identification of protein phosphorylation. Anal Chem. 2009;81:7778 – 87.
10
Lu H, Zong C, Wang Y, Young GW, Deng N, Souda P, Li X, Whitelegge J, Drews O, Yang PY, Ping P . Revealing the dynamics of 20S proteasome phosphoproteome: a combined CID and ETD approach. Mol Cell Proteomics. 2008 Jun 25. [Epub ahead of print]
11
Zhang J, Liem DA, Mueller M, Wang Y, Zong C, Deng N, Vondriska TM, Korge P, Drews O, Maclellan WR, Honda H, Weiss JN, Apweiler R, Ping P . Altered proteome biology of cardiac mitochondria under stress conditions. J Proteome Res. 2008;7:2204 – 14.
12
Ping P , Bergeron J, Apweiler R. Wiley-VCH and HUPO: a global effort to advance proteomic science. Proteomics. 2008;8:4 – 6.
13
Warburton S, White MY, Van Eyk JE, Cotter RJ, Ping P , Dunn MJ, Vondriska TM. Cardiovascular Initiative of the Human Proteome Organisation, 5 ^th Workshop October 2007, Seoul, Korea. Proteomics. 2008;8:924 – 6.
14
Baldán A, Gomes AV, Ping P , Edwards PA. Loss of ABCG1 results in chronic pulmonary inflammation. J Immunol. 2008;180:3560 – 8.
15
Zhang J, Li X, Mueller M, Wang Y, Zong C, Deng N, Vondriska TM, Liem DA, Yang JI, Korge P, Honda H, Weiss JN, Apweiler R, Ping P . Systematic characterization of the murine mitochondrial proteome using functionally validated cardiac mitochondria. Proteomics. 2008;8:1564 – 75.
16
Young GW, Wang Y, Ping P . Understanding proteasome assembly and regulation: importance to cardiovascular medicine. Trends Cardiovasc Med. 2008;18:93 – 8.
17
Zong C, Young GW, Wang Y, Lu H, Deng N, Drews O, Ping P . Two-dimensional electrophoresis-based characterization of post-translational modifications of mammalian 20S proteasome complexes. Proteomics. 2008;8:5025 – 37.
18
Orchard S, Ping P . HUPO World Congress Publication Committee meeting. August 2008, Amsterdam, The Netherlands. Proteomics. 2009;9:502 – 3.
19
Zhang J, Liem DA, Mueller M, Wang Y, Zong C, Deng N, Vondriska TM, Korge P, Drews O, Maclellan WR, Honda H, Weiss JN, Apweiler R, Ping P . Altered proteome biology of cardiac mitochondria under stress conditions. J Proteome Res. 2008;7:2204 – 14.
20
Ye WJ, Ping P , Liu YD, Li Z, Huang YR. Single stage dorsal inlay buccal mucosal graft with tubularized incised urethral plate technique for hypospadias reoperations. Asian J Androl. 2008;10:682 – 6.
21
Lu H, Zong C, Wang Y, Young GW, Deng N, Souda P, Li X, Whitelegge J, Drews O, Yang PY, Ping P . Revealing the dynamics of the 20 S proteasome phosphoproteome: a combined CID and electron transfer dissociation approach. Mol Cell Proteomics. 2008;7:2073 – 89.
22
Liem DA, Zhao P, Angelis E, Chan SS, Zhang J, Wang G, Berthet C, Kaldis P, Ping P , MacLellan WR. Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J Mol Cell Cardiol. 2008;45:610 – 6.
23
Korge P, Ping P , Weiss JN. Reactive oxygen species production in energized cardiac mitochondria during hypoxia/reoxygenation: modulation by nitric oxide. Circ Res. 2008;103:873 – 80.
24
Jiang H, Shang XJ, Guo J, Li Z, Zhao LM, Shao Y, Ping P , Huang YF, Zhu JC. [Multi-centered clinical trial of Fufang Xuanju capsule for oligoasthenospermia]. Zhonghua Nan Ke Xue. 2008;14:755 – 8.
25
Chen R, Fu MG, Lu Y, Wang L, Ping P , Fan ZH. [Effects of antisense oligonucleotides on the expression of focal adhesion kinase gene and collagen sythesis in the cultured human fibroblasts of hypertrophic scar]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2008;24:475 – 7.
26
Drake TA, Ping P . Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Proteomics approaches to the systems biology of cardiovascular diseases. J Lipid Res. 2007;48:1 – 8.
27
Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P , Wiita P, Bok D, Sun H. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 2007;315:820 – 5.
28
Orchard S, Heck A, Uhlen M, Ping P . Publication Committee meeting. HUPO 5 ^th annual World Congress. Long Beach, CA, USA 30 October 2006 . Proteomics. 2007;7:1009 – 11.
29
Drews O, Zong C, Ping P . Exploring proteasome complexes by proteomic approaches. Proteomics. 2007;7:1047 – 58.
30
Drews O, Wildgruber R, Zong C, Sukop U, Nissum M, Weber G, Gomes AV, Ping P . Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol Cell Proteomics. 2007;6:2021 – 31.
31
Liem DA, Honda HM, Zhang J, Woo D, Ping P . Past and present course of cardioprotection against ischemia-reperfusion injury. J Appl Physiol. 2007;103:2129 – 36.
32
Taylor CF, Paton NW, Lilley KS, Binz PA, Julian RK Jr, Jones AR, Zhu W, Apweiler R, Aebersold R, Deutsch EW, Dunn MJ, Heck AJ, Leitner A, Macht M, Mann M, Martens L, Neubert TA, Patterson SD, Ping P , Seymour SL, Souda P, Tsugita A, Vandekerckhove J, Vondriska TM, Whitelegge JP, Wilkins MR, Xenarios I, Yates JR 3 ^rd, Hermjakob H. The minimum information about a proteomics experiment (MIAPE). Nat Biotechnol. 2007;25:887 – 93.
33
Hai-Long H, Jian Z, Ping-Ping Y, Liang C, Xun L, Shan ZZ, Yan-Sheng Y. Genetic characterization of CRF01_AE full-length human immunodeficiency virus type 1 sequences from Fujian, China. AIDS Res Hum Retroviruses. 2007;23:569 – 74.
34
Chun-mao H, Su-yi W, Ping-ping L, Hang-hui C. Human bone marrow-derived mesenchymal stem cells differentiate into epidermal-like cells in vitro. Differentiation. 2007;75:292 – 8.
35
Abdellatif AA, Pelt JL, Benton RL, Howard RM, Tsoulfas P, Ping P , Xu XM, Whittemore SR. Gene delivery to the spinal cord: comparison between lentiviral, adenoviral, and retroviral vector delivery systems. J Neurosci Res. 2006;84:553 – 67.
36
Zong C, Gomes AV, Drews O, Li X, Young GW, Berhane B, Qiao X, French SW, Bardag-Gorce F, Ping P . Regulation of murine cardiac 20S proteasomes: role of associating partners. Circ Res. 2006;99:372 – 80.
37
Orchard S, Ping P . HUPO Publications Committee Meeting: 21 April 2006, San Francisco, CA, USA . Proteomics. 2006;6:4436 – 8.
38
Mayr M, Zhang J, Greene AS, Gutterman D, Perloff J, Ping P . Proteomic based development of biomarkers in cardiovascular disease: mechanistic, clinical, and therapeutic insights. Mol Cell Proteomics. 2006;5:1853 – 1864.
39
Gomes AV, Zong C, Ping P . Protein degradation by the 26S proteasome system in the normal and stressed myocardium. Antioxid Redox Signal. 2006;8:1677 – 91.
40
Gomes AV, Zong C, Edmondson RD, Li X, Stefani E, Zhang J, Jones RC, Thyparambil S, Wang GW, Qiao X, Bardag-Gorce F, Ping P . Mapping the murine cardiac 26S proteasome complexes. Circ Res. 2006;99:362 – 71.
41
Arab S, Gramolini AO, Ping P , Kislinger T, Stanley B, van Eyk J, Ouzounian M, MacLennan DH, Emili A, Liu PP. Cardiovascular proteomics: tools to develop novel biomarkers and potential applications. J Am Coll Cardiol. 2006;48:1733 – 41.
42
Honda HM, Ping P . Mitochondrial permeability transition in cardiac cell injury and death. Cardiovasc Drugs Ther. 2006;20:425 – 32.
43
Li Q, Ping P , Jiang H, Liu K. Nerve conduit filled with GDNF gene-modified Schwann cells enhances regeneration of the peripheral nerve. Microsurgery. 2006;26:116 – 21.
44
Zhang J, Baines CP, Zong C, Cardwell EM, Wang G, Vondriska TM, Ping P . Functional proteomic analysis of a three-tier PKCepsilon-Akt-eNOS signaling module in cardiac protection. Am J Physiol Heart Circ Physiol. 2005;288:H954-61 .
45
Wang G, Liem DA, Vondriska TM, Honda HM, Korge P, Pantaleon DM, Qiao X, Wang Y, Weiss JN, Ping P . Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. Am J Physiol Heart Circ Physiol. 2005;288:H1290-5 .
46
Ping P , Vondriska TM, Creighton CJ, Gandhi TK, Yang Z, Menon R, Kwon, MS, Cho SY, Drwal G, Kellmann M, Peri S, Suresh S, Gronborg M, Molina H, Chaerkady R, Rekha B, Shet AS, Gerszten RE, Wu H, Raftery M, Wasinger V, Schulz-Knappe P, Hanash SM, Paik YK, Hancock WS, States DJ, Omenn GS, Pandey A. A functional annotation of subproteomes in human plasma. Proteomics. 2005;5:3506 – 19.
47
Omenn GS, States DJ, Adamski M, Blackwell TW, Menon R, Hermjakob H, Apweiler R, Haab BB, Simpson RJ, Eddes JA, Kapp EA, Moritz RL, Chan DW, Rai AJ, Admon A, Aebersold R, Eng J, Hancock WS, Hefta SA, Meyer H, Paik YK, Yoo JS, Ping P , Pounds J, Adkins J, Qian X, Wang R, Wasinger V, Wu CY, Zhao X, Zeng R, Archakov A, Tsugita A, Beer I, Pandey A, Pisano M, Andrews P, Tammen H, Speicher DW, Hanash SM. Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics. 2005;5:3226 – 45.
48
Omenn GS, Ping P . HUPO 3 ^rd annual World Congress on Proteomics. 25-27 ^th October, 2004, Beijing, China. Expert Rev Proteomics. 2005;2:9 – 12.
49
McCarthy J, McLeod CJ, Minners J, Essop MF, Ping P , Sack MN. PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve – a putative mechanism in PKCepsilon cardioprotection. J Mol Cell Cardiol. 2005;38:697 – 700.
50
Gomes AV, Zong C, Edmondson RD, Berhane BT, Wang GW, Le S, Young G, Zhang J, Vondriska TM, Whitelegge JP, Jones RC, Joshua IG, Thyparambil S, Pantaleon, D, Qiao J, Loo J, Ping P . The murine cardiac 26S proteasome: an organelle awaiting exploration. Ann N Y Acad Sci. 2005;1047:197 – 207.
51
Cao Q, Xu XM, Devries WH, Enzmann GU, Ping P , Tsoulfas P, Wood PM, Bunge MB, Whittemore SR. Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci. 2005;25:6947 – 57.
52
Berhane BT, Zong C, Liem DA, Huang A, Le S, Edmondson RD, Jones RC, Qiao X, Whitelegge JP, Ping P , Vondriska TM. Cardiovascular-related proteins identified in human plasma by the HUPO Plasma Proteome Project pilot phase. Proteomics. 2005;5:3520 – 30.
53
Liem DA , Wang GW, Vondriska TM, Honda HM, Qiao X, Korge P, Pantaleon DM, Wang Y, Weiss JN, Ping P . Nitric oxide induces late phase preconditioning against myocardial infarction via modulation of mitochondrial permeability transition. Am J Physiol. 2005;288:H1290-5
54
Ping P , Wang W, Chen X, Jing X. Poly(epsilon-caprolactone) polyurethane and its shape-memory property. Biomacromolecules. 2005;6:587 – 92.
55
Doble BW, Dang X, Ping P , Fandrich RR, Nickel BE, Jin Y, Cattini PA, Kardami E. Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. J Cell Sci. 2004;117:507 – 14.
56
Zhang J, Ping P , Wang GW, Lu M, Pantaleon D, Tang XL, Bolli R, Vondriska TM. Bmx, a member of the Tec family of nonreceptor tyrosine kinases, is a novel participant in pharmacological cardioprotection. Am J Physiol Heart Circ Physiol. 2004;287:H2364-6 .
57
Vondriska TM, Pass JM, Ping P . Scaffold proteins and assembly of multiprotein signaling complexes. J Mol Cell Cardiol. 2004;37:391 – 7.
58
MacLellan WR, Ping P , Vondriska T. Heart disease leaves its mark: proteomics-based biosignatures in acute coronary syndromes. J Am Coll Cardiol. 2004;44:1584 – 6.
59
Ping P . Identification of novel signaling complexes by functional proteomics. Circ Res. 2003 Oct 3;93(7):595 – 603.
60
Vondriska TM, Ping P . Multiprotein signaling complexes and regulation of cardiac phenotype. J Mol Cell Cardiol. 2003 Sep;35:1027 – 33.
61
Tang XL, Kodani E, Takano H, Hill M, Shinmura K, Vondriska TM, Ping P , Bolli R. Protein tyrosine kinase signaling is necessary for NO donor-induced late preconditioning against myocardial stunning. Am J Physiol Heart Circ Physiol. 2003;284:H1441-8 .
62
Baines CP, Song CX, Zheng YT, Wang GW, Zhang J, Wang OL, Guo Y, Bolli R, Cardwell EM, Ping P . Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria. Circ Res. 2003;92:873 – 80.
63
Prabhu SD, Wang G, Luo J, Gu Y, Ping P , Chandrasekar B. Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium. J Mol Cell Cardiol. 2003;35:483 – 93.
64
Ping P . A new chapter in cardiac PKC signaling studies: searching for isoform-specific molecular targets. Focus on: “isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes”. Am J Physiol Cell Physiol. 2003;285:C19-21 .
65
Zhang J, Ping P , Vondriska TM, Tang XL, Wang GW, Cardwell EM, Bolli R. Cardioprotection involves activation of NF-kappa B via PKC-dependent tyrosine and serine phosphorylation of I kappa B-alpha. Am J Physiol Heart Circ Physiol. 2003;285:H1753-8 .
66
Pass JM, Zhang J, Vondriska TM, Ping P . Functional proteomic analysis of the protein kinase C signaling system. Methods Mol Biol. 2003;233:369 – 85.
67
Weiss JN, Korge P, Honda HM, Ping P . Role of the mitochondrial permeability transition in myocardial disease. Circ Res. 2003;93:292 – 301.
68
Ping P , Baines CP, Gu Y, Prabhu SD, Zhang J, Tsai LL, Cardwell E, Zong NC, Vondriska TM, Korge P, Bhatnagar A, Wang GW. Cardiac toxic effects of trans-2-hexenal are mediated by induction of cardiomyocyte apoptotic pathways. Cardiovasc Toxicol. 2003;3:341 – 51.
69
Ping P , Li QF, Zhang DS. [An experiment study on repair of peripheral nerve defects by GDNF gene modified Schwann cells]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2003;19:369 – 72.
70
Song C, Vondriska TM, Wang GW, Klein JB, Cao X, Zhang J, Kang YJ, D’Souza S, Ping P . Molecular conformation dictates signaling module formation: example of PKCe and Src tyrosine kinase. Am J Physiol Heart Circ Physiol. 2002;282:H1166-71 .
71
Balafanova Z, Bolli R, Zhang J, Zheng Y, Pass JM, Bhatnagar A, Tang XL, Wang O, Cardwell E, Ping P . Nitric oxide (NO) induces nitration of protein kinase C epsilon (PKCe), facilitating PKCe enhanced PKCe-RACK2 interactions: a novel mechanism of no-triggered activation of PKCe. J Biol Chem. 2002;277:15021 – 15027.
72
Ping P , Song C, Zhang J, Guo Y, Cao X, Li RC, Wu W, Vondriska TM, Pass JM, Tang XL, Pierce WM, Bolli R. Formation of protein kinase Ce-Lck signaling modules confers cardioprotection. J Clin Invest. 2002;109:499 – 507.
73
Baines CP, Zhang J, Wang GW, Zheng YT, Xiu JX, Cardwell EM, Bolli R, Ping P . Mitochondrial PKCe and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCe-MAPK interactions and differential MAPK activation in PKCe-induced cardioprotection. Circ Res. 2002;90:390 – 7.
74
Cross HR, Murphy E, Bolli R, Ping P , Steenbergen C. Expression of activated PKC epsilon (PKCe) protects the ischemic heart, without attenuating ischemic H(+) production. J Mol Cell Cardiol. 2002;34:361 – 7.
75
Edmondson RD, Vondriska TM, Biederman KJ, Zhang J, Jones RC, Zheng Y, Allen DL, Xiu JX, Cardwell EM, Pisano MR, Ping P . Protein kinase C e signaling complexes include metabolism– and transcription/translation-related proteins: complimentary separation techniques with LC/MS/MS. Mol Cell Proteomics. 2002;1:421 – 33.
76
Vondriska TM, Ping P . Functional proteomics to study protection of the ischaemic myocardium. Expert Opin Ther Targets. 2002;6:563 – 70.
77
Li Q, Ping P , Zhang D. [Vascular endothelial growth factor (VEGF) accelerates maturation of prefabricated flap]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2002;18:69 – 71.
78
Wang JF, Yang Y, Wang G, Min J, Sullivan MF, Ping P , Xiao YF, Morgan JP. Embryonic stem cells attenuate viral myocarditis in murine model. Cell Transplant. 2002;11:753 – 8.
79
Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P , McLeish KR. p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem. 2001;276:3517 – 23.
80
Ping P , Zhang J, Pierce WM Jr, Bolli R. Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection. Circ Res. 2001;88:59 – 62.
81
Pass JM, Zheng Y, Wead WB, Zhang J, Li RC, Bolli R, Ping P . PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression. Am J Physiol Heart Circ Physiol. 2001;280:H946-55 .
82
Vondriska TM, Klein JB, Ping P . Use of functional proteomics to investigate PKC epsilon-mediated cardioprotection: the signaling module hypothesis. Am J Physiol Heart Circ Physiol. 2001;280:H1434-41 .
83
Baines CP, Pass JM, Ping P . Protein kinases and kinase-modulated effectors in the late phase of ischemic preconditioning. Basic Res Cardiol. 2001;96:207 – 18.
84
Vondriska TM, Zhang J, Song C, Tang XL, Cao X, Baines CP, Pass JM, Wang S, Bolli R, Ping P . Protein kinase C epsilon-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling . Circ Res . 2001;88:1306 – 13.
85
Pass JM, Gao J, Jones WK, Wead WB, Wu X, Zhang J, Baines CP, Bolli R, Zheng YT, Joshua IG, Ping P . Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1 . Am J Physiol Heart Circ Physiol . 2001;281:H2500-10 .
86
Doble BW, Ping P , Fandrich RR, Cattini PA, Kardami E. Protein kinase C-e mediates phorbol ester-induced phosphorylation of connexin-43 . Cell Adhes Commun . 2001;8:253 – 6.
87
Doble BW, Ping P , Kardami E. The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation . Circ Res . 2000;86:293 – 301.
88
Ping P , Murphy E. Role of p38 mitogen-activated protein kinases in preconditioning: a detrimental factor or a protective kinase ? Circ Res . 2000;86:921 – 2.
89
Takeishi Y, Ping P , Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA. Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy . Circ Res . 2000;86:1218 – 23.
90
Li RC, Ping P , Zhang J, Wead WB, Cao X, Gao J, Zheng Y, Huang S, Han J, Bolli R. PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes . Am J Physiol Heart Circ Physiol . 2000;279:H1679-89 .
91
Ping P , Li QF, Gan JL. [Neurobiological effect of nerve regeneration conditioned fluid on motoneuron]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2000;14:325 – 7.
92
Ping P , Takano H, Zhang J, Tang XL, Qiu Y, Li RC, Banerjee S, Dawn B, Balafanova Z, Bolli R. Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning . Circ Res . 1999;84:587 – 604.
93
Ping P , Zhang J, Cao X, Li RC, Kong D, Tang XL, Qiu Y, Manchikalapudi S, Auchampach JA, Black RG, Bolli R. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits . Am J Physiol . 1999;276:H1468-81 .
94
Ping P , Zhang J, Zheng YT, Li RC, Dawn B, Tang XL, Takano H, Balafanova Z, Bolli R. Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits . Circ Res . 1999;85:542 – 50.
95
Ping P , Zhang J, Huang S, Cao X, Tang XL, Li RC, Zheng YT, Qiu Y, Clerk A, Sugden P, Han J, Bolli R. PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits . Am J Physiol . 1999;277:H1771-85 .
96
Guo Y, Jones WK, Xuan YT, Tang XL, Bao W, Wu WJ, Han H, Laubach VE, Ping P , Yang Z, Qiu Y, Bolli R. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene . Proc Natl Acad Sci U S A . 1999;96:11507 – 12.
97
Dawn B, Xuan YT, Qiu Y, Takano H, Tang XL, Ping P , Banerjee S, Hill M, Bolli R. Bifunctional role of protein tyrosine kinases in late preconditioning against myocardial stunning in conscious rabbits . Circ Res . 1999;85:1154 – 63.
98
Hammond HK, Ping P , Insel PA. Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor antagonist . Adv Pharmacol . 1998;42:507 – 10.
99
Gao M, Ping P , Post S, Insel PA, Tang R, Hammond HK. Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes . Proc Natl Acad Sci U S A . 1998;95:1038 – 43.
100
Pal M, Toth A, Ping P , Johnson PC. Capillary blood flow and tissue metabolism in skeletal muscle during sympathetic trunk stimulation . Am J Physiol . 1998;274:H430-40 .
101
Qiu Y, Ping P , Tang XL, Manchikalapudi S, Rizvi A, Zhang J, Takano H, Wu WJ, Teschner S, Bolli R. Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved . J Clin Invest . 1998;101:2182 – 98.
102
Bolli R, Dawn B, Tang XL, Qiu Y, Ping P , Xuan YT, Jones WK, Takano H, Guo Y, Zhang J. The nitric oxide hypothesis of late preconditioning . Basic Res Cardiol . 1998;93:325 – 38.
103
Ping P , Anzai T, Gao M, Hammond HK. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure . Am J Physiol . 1997;273:H707-17 .
104
Ping P , Zhang J, Qiu Y, Tang XL, Manchikalapudi S, Cao X, Bolli R. Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity . Circ Res . 1997;81:404 – 14.
105
Giordano FJ, Ping P , McKirnan MD, Nozaki S, DeMaria AN, Dillmann WH, Mathieu-Costello O, Hammond HK. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart . Nat Med . 1996;2:534 – 9.
106
Ping P , Yang Q, Hammond HK. Altered beta-adrenergic receptor signaling in heart failure, in vivo gene transfer via adeno and adeno-associated virus . Microcirculation . 1996;3:225 – 8.
107
Ping P , Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart . J Clin Invest . 1995;95:1271 – 80.
108
Ping P , Johnson PC. Arteriolar network response to pressure reduction during sympathetic nerve stimulation in cat skeletal muscle . Am J Physiol . 1994;266:H1251-9 .
109
Ping P , Hammond HK. Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts . Am J Physiol . 1994;267:H2079-85 .
110
Hammond HK, Roth DA, McKirnan MD, Ping P . Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia . J Clin Invest . 1993 Dec;92:2644 – 52.
111
Ping P , Faber JE. Characterization of alpha-adrenoceptor gene expression in arterial and venous smooth muscle . Am J Physiol . 1993;265:H1501-9 .
112
Ping P , Johnson PC. Mechanism of enhanced myogenic response in arterioles during sympathetic nerve stimulation . Am J Physiol . 1992;263:H1185-9 .
113
Ping P , Johnson PC. Role of myogenic response in enhancing autoregulation of flow during sympathetic nerve stimulation . Am J Physiol . 1992;263:H1177-84 .

The Cardiac Proteomics & Signaling Laboratory at UCLA

Peipei Ping, PhD FAHA

publications by Peipei Ping

Other Lab Members