The Cardiac Proteomics & Signaling Laboratory at UCLA

Our research pro­gram focu­ses on the cha­rac­te­ri­za­tion of sig­na­ling path­ways and cellu­lar orga­ne­lles in the heart, with a par­ti­cu­lar inte­rest on alte­ra­tions of sub­pro­teo­mes during myo­car­dial ische­mic injury. Since 1992, this research pro­gram has autho­red 110 manusc­ripts in car­diac cell sig­na­ling and myo­car­dial ische­mic injury. The func­tio­nal pro­teo­mic approaches we employ have pro­vi­ded key infor­ma­tion per­tai­ning to the pro­teo­mic basis of disea­sed car­diac phe­noty­pes, and ena­bled a holis­tic por­trait of mul­ti­ple mole­cu­les and path­ways in para­llel. The pro­teo­mic deli­nea­tion com­bi­ned with gene­tic inte­rro­ga­tions has been effec­tive to gain insights of patho­ge­ne­sis in heart disea­ses. Dr. Pei­pei Ping, the Direc­tor of our research pro­gram, sum­ma­ri­zes our mis­sion as “To pro­vide an envi­ron­ment for stu­dents, fellows, and collea­gues for crea­tive work; to remind ever­yone to share and to enjoy the roses in our life.”